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Madhav Thambisetty, M.D., Ph.D., Clinical Investigator and Chief,
Unit of Clinical and Translational Neuroscience

Madhav Thambisetty, M.D., Ph.D.

Dr. Thambisetty is a Board-certified neurologist with sub-specialty training in cognitive/behavioral neurology and sleep disorders. He completed both residency and fellowship training in the Department of Neurology at Emory University School of Medicine in Atlanta. Prior to training in Neurology, he was awarded a PhD (DPhil) in Clinical Pharmacology from the University of Oxford where he pursued his doctoral studies on a Felix scholarship. His PhD thesis examined the role of synaptic remodeling in the actions of anti-depressant treatments. In 2004, he was awarded a research fellowship by the Alzheimer’s Society of the United Kingdom to pursue research into ‘Proteomic and Neuroimaging Approaches to Peripheral Biomarkers of Alzheimer’s Disease’ at the Institute of Psychiatry, King’s College, London. He was elected to the Emanoel Lee medical research fellowship at St. Cross College, Oxford in 2004. He is currently also an Adjunct Associate Professor of Neurology at the Johns Hopkins University School of Medicine and evaluates patients referred to the Bayview Memory and Alzheimer’s Treatment Center (MATC).

The goals of the Unit of Clinical and Translational Neuroscience are to enhance understanding of disease mechanisms operating in AD as well as to identify novel biomarkers that might be predictive of disease before the onset of clinical symptoms. To achieve these goals, we use several approaches including:

1. Applying mass spectrometry-based proteomics and metabolomics for the discovery of novel biomarkers predictive of disease before symptom onset.

2. Relating genetic and environmental risk factors to changes in brain structure, function and pathology during aging.

While these studies rely primarily on clinical and neuroimaging datasets available within the Baltimore Longitudinal Study of Aging (BLSA), other datasets, such as those available through the Alzheimer's Disease Neuroimaging Initiative (ADNI) and National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) are also used in these analyses.

In our biomarker discovery studies, we use archived blood samples collected through the BLSA to identify changes over time in the concentrations of proteins and small metabolites that may be predictive of early cognitive decline and neuropathological changes associated with AD.

Contact Information:
Laboratory of Behavioral Neuroscience
Unit of Clinical and Translational Neuroscience
NIA/IRP Biomedical Research Center
251 Bayview Blvd
Baltimore, MD 21224

Phone 410-558-8572
Fax 410-558-8302
E mail:

For more information about the Laboratory:

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Updated: Tuesday March 11, 2014