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Mark P. Mattson, Ph.D., Senior Investigator
Chief, Laboratory of Neurosciences and
Chief, Cellular and Molecular Neurosciences Section
Mark P. Mattson, Ph.D.

Dr. Mattson received his Ph.D. in Biology from the University of Iowa in 1986. After 3 years of postdoctoral studies in Developmental Neuroscience at Colorado State University, Dr. Mattson took a faculty position at the Sanders-Brown Research Center on Aging at the University of Kentucky Medical Center where he was promoted to Full Professor in 1997. Dr. Mattson is currently Chief of the Laboratory of Neurosciences at the National Institute on Aging, and Professor of Neuroscience at Johns Hopkins University. He is Editor-in-Chief of Ageing Research Reviews and NeuroMolecular Medicine, a Section Editor for Neurobiology of Aging, and an Associate Editor for Trends in Neurosciences.  In addition, he has edited 10 volumes in the areas of mechanisms of brain function, stress responses, aging and age-related neurodegenerative disorders.  Dr. Mattson is a Fellow of the American Association for the Advancement of Science, and has received numerous awards including the Metropolitan Life Foundation Medical Research Award and the Alzheimer's Association Zenith Award. He is considered a leader in the area of cellular and molecular mechanisms underlying neuronal plasticity and neurodegenerative disorders, and has made major contributions to understanding of the pathogenesis of Alzheimer's disease, and to its prevention and treatment.  Dr. Mattson has published more than 400 original research articles and more than 200 review articles and commentaries.

Research Interests: The Cellular and Molecular Neurosciences Section (CMNS) employs a multifaceted array of experimental models of aging and age-related neurodegenerative disorders in order to establish the molecular and biochemical changes that occur during aging and in disorders such as Alzheimer's, Parkinson's and Huntington's diseases and stroke. Data obtained in these experimental models are integrated with data obtained in studies of both normal elderly humans and patients with neurodegenerative disorders to arrive at conclusions as to why neuronal dysfunction and degeneration occur in the disorders. An area of focus is aimed at understanding adaptive cellular stress responses in neurons, and how they can be activated by behavioral and pharmacological interventions so as to protect the brain against injury and disease.   Discoveries made in animal models in the laboratory are being translated into preclinical studies and clinical trials in human subjects.

Contact Information:
Laboratory of Neurosciences
Biomedical Research Center, 05C214
251 Bayview Boulevard, Suite 100
Baltimore, MD 21224-6825

Phone 410-558-8463
Fax 410-558-8465
E mail

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Updated: Wednesday November 28, 2012